GH Secretagogues
Tesamorelin
Scientific Profile
Tesamorelin is a growth hormone-releasing factor analog with a fatty acid moiety attached to the N-terminus. In vitro studies demonstrate high affinity binding to GHRH receptors, stimulating GH release. The fatty acid modification confers albumin binding properties, significantly extending its half-life in biological systems.
Animal models show sustained activation of GHRH receptors with prolonged GH secretion. The peptide demonstrates resistance to proteolytic degradation due to its structural modifications.