GH Secretagogues
Hexarelin
Scientific Profile
Hexarelin (His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2) is a synthetic hexapeptide growth hormone secretagogue derived from the GHRP-6 scaffold. In vitro studies demonstrate high affinity binding to the growth hormone secretagogue receptor GHS-R1a, activating phospholipase C signaling in the same manner as the other GHRPs. The 2-methyl substitution on the D-tryptophan residue distinguishes it from GHRP-6 and increases metabolic stability.
Animal research additionally reports binding to CD36 in cardiac tissue, a receptor interaction independent of the GH axis. Its D-amino acid content confers resistance to enzymatic degradation.
This profile was compiled in-house and is not part of the published compendium.
This compendium provides objective scientific information on research peptides based solely on published literature. All descriptions are limited to biochemical properties and mechanisms observed in in-vitro or animal studies, with no implications regarding human efficacy or therapeutic applications.