Metabolic & GLP-1 Analogues
Cagrilintide
Scientific Profile
Cagrilintide is a long-acting amylin analog with amino acid modifications that enhance its stability and receptor binding affinity. In preclinical studies, this peptide demonstrates high affinity for amylin receptors (AMY1-3) with prolonged half-life due to albumin binding properties.
Animal research indicates significant effects on gastric emptying and glucagon suppression. The structural modifications, including fatty acid acylation, contribute to its extended pharmacokinetic profile in experimental models.