Longevity & Cellular
MOTS-c
Scientific Profile
MOTS-C (Mitochondrial-Derived Peptide) is a 16-amino acid peptide encoded by mitochondrial DNA (Met-Arg-Trp-Gln-Glu-Met-Gly-Ile-Phe-Ser-Leu-Arg-Asp-Leu-Asp-Phe). In vitro studies demonstrate its ability to regulate metabolic homeostasis through AMPK activation and folate metabolism modulation.
Research indicates MOTS-C translocates to the nucleus under stress conditions, regulating gene expression. Animal models show improved insulin sensitivity and metabolic parameters through modulation of glucose metabolism and mitochondrial function.
This compendium provides objective scientific information on research peptides based solely on published literature. All descriptions are limited to biochemical properties and mechanisms observed in in-vitro or animal studies, with no implications regarding human efficacy or therapeutic applications.