Longevity & Cellular
FOXO4-DRI
Scientific Profile
FOXO4-DRI is a cell-penetrating peptide designed to disrupt the interaction between FOXO4 and p53 proteins. In cellular senescence models, this peptide selectively induces apoptosis in senescent cells by interfering with the FOXO4-p53 binding that maintains cellular viability.
Research demonstrates that FOXO4-DRI effectively reduces senescent cell burden in aged mice, improving physical function and tissue homeostasis. The peptide's D-retro inverso configuration enhances its proteolytic stability.
This compendium provides objective scientific information on research peptides based solely on published literature. All descriptions are limited to biochemical properties and mechanisms observed in in-vitro or animal studies, with no implications regarding human efficacy or therapeutic applications.