GH Secretagogues
HGH (Human Growth Hormone, Somatropin)
Scientific Profile
Human Growth Hormone (Somatropin) is a 191-amino acid single-chain polypeptide with two disulfide bridges. Recombinant HGH produced in E. coli demonstrates identical amino acid sequence and biological activity to native pituitary GH.
In vitro studies confirm its ability to bind GH receptors, activating JAK2-STAT5 signaling pathways. The protein exhibits specific conformational requirements for receptor interaction, with the third alpha-helix being particularly crucial for biological activity in experimental models.
This compendium provides objective scientific information on research peptides based solely on published literature. All descriptions are limited to biochemical properties and mechanisms observed in in-vitro or animal studies, with no implications regarding human efficacy or therapeutic applications.